Investigation into in vitro anti-leishmanial combinations of calcium channel blockers and current anti-leishmanial drugs

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Investigation into in vitro anti-leishmanial combinations of calcium channel blockers and current anti-leishmanial drugs.

The need for drug combinations to treat visceral leishmaniasis (VL) arose because of resistance to antimonials, the toxicity of current treatments and the length of the course of therapy. Calcium channel blockers (CCBs) have shown anti-leishmanial activity; therefore their use in combination with standard drugs could provide new alternatives for the treatment of VL. In this work, in vitro isobo...

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Leishmaniasis is one of the most diverse and complex vector-borne metazoonosis diseases[1]. The causing agent is at least 17 species[2] of obligate intracellular protozoan parasites that belong to the genus Leishmania[3]. It is transmitted to human by the bite of phlebotomine female sand flies of the genera Phlebotomus and Lutzomyia in the old and new worlds respectively[4]. The species are in ...

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In vitro activity of anti-leishmanial drugs against Leishmania donovani is host cell dependent.

OBJECTIVES To evaluate the in vitro activity of anti-leishmanial drugs against intracellular Leishmania donovani amastigotes in different types of macrophages. METHODS Mouse peritoneal macrophages (PEMs), mouse bone marrow-derived macrophages (BMMPhi), human peripheral blood monocyte-derived macrophages (PBM Phi) and differentiated THP-1 cells were infected with L. donovani. Cultures were inc...

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ژورنال

عنوان ژورنال: Memórias do Instituto Oswaldo Cruz

سال: 2011

ISSN: 0074-0276

DOI: 10.1590/s0074-02762011000800022